country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-W1142089

Copy Link Print Information

ActRIIB-IN-2

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3039974-32-5
分子式: C₂₆H₂₅N₅
分子量:407.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-2 構造式

CAS 番号: 3039974-32-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia^[1].

IC₅₀ & Target

^[1]

ACVR2B

1.1 nM (IC₅₀)

TGF-β Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

ActRIIB-IN-2 (2.5 μM; 48 h) achieved a 90.87% reversal rate in myotube atrophy^[1].
ActRIIB-IN-2 (Compound 3) potently inhibits ActRIIB in a cell-free biochemical assay with an IC₅₀ of 1.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

ActRIIB-IN-2 (10 mg/kg; daily for 16 days) alleviates weight loss, muscle atrophy, and muscle strength in BABL/c mice inoculated with CT26 cells without affecting tumor size, and slightly improves appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (inoculated with 1 million C26 cells in each axilla to establish a colon cancer model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; daily for 16 days
Result:

Alleviated weight loss to some extent.
Reduced tumor volume, but not significantly.
Improved appetite.
Significantly enhanced muscle grip strength.
Improved skeletal muscle atrophy to some extent.
Significantly alleviated the reduction in the cross-sectional area of the gastrocnemius muscle.

化学情報

CAS 番号 3039974-32-5
分子量 407.51
分子式 C₂₆H₂₅N₅
SMILES

CN(CC1)CCN1C(C=C2)=CC=C2C3=CC4=C(NC=C4C5=CC6=C(NC=C6)C=C5)N=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dong XC, et al. 7-azaindole compounds, preparation method therefor, and use thereof. China, WO2024114661 A. 2024-06-06.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ