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製品番号: HY-N19313

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Agelastatin D

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 201338-45-6
分子式: C₁₁H₁₁BrN₄O₃
分子量:327.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Agelastatin D 構造式

CAS 番号: 201338-45-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	13.7 μM Compound: 2b	Antitumor activity against human HeLa cells assessed as cell viability by MTT assay Antitumor activity against human HeLa cells assessed as cell viability by MTT assay	[PMID: 24673739]

体外実験

Agelastatin D (compound 2b) exhibits cytotoxic activity against CLL1, CLL2, JVM-2, and HeLa cell lines with EC₅₀ values at 48 h of 91.1 μM, 29.0 μM, 13.2 μM, and 13.7 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

primary chronic lymphocytic leukemia (CLL) patient cell lines (CLL1, CLL2), immortalized leukemic JVM-2 cell line, HeLa cell line
Concentration:

dose-response format (CLL1, CLL2, JVM-2); dose-response format (HeLa)
Incubation Time:

48 h (CLL1, CLL2, JVM-2); overnight (HeLa)
Result:

Exhibited cytotoxic activity with EC₅₀ values of 91.1 μM (CLL1), 29.0 μM (CLL2), 13.2 μM (JVM-2), and 13.7 μM (HeLa).

化学情報

CAS 番号 201338-45-6
分子量 327.13
分子式 C₁₁H₁₁BrN₄O₃
SMILES

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(NC(N4)=O)O)=CC=C1C3=O
Structure Classification
- Others
Initial Source
- Animals
Cymbastela sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Stout EP, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014;57(12):5085-5093. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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