ALK5-IN-9
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2489611-06-3
- 分子式: C29H35F3N6O3
- 分子量:572.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
74.6 nM
Compound: 8h
|
Antiproliferative activity against mouse NIH/3T3 cells assessed as cell growth inhibition
Antiproliferative activity against mouse NIH/3T3 cells assessed as cell growth inhibition
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[PMID: 35051574] |
化学情報
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CAS 番号 2489611-06-3
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分子量 572.62
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分子式 C29H35F3N6O3
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SMILES
OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ALK5-IN-9 関連分類
HY-144437 関連分類
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