Anticancer agent 118
Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 864443-43-6
- 分子式: C19H19ClFN3O4
- 分子量:407.82
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
10 μM
Compound: 2
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Antitumor activity against human A549 cells after 5 days by MTT assay
Antitumor activity against human A549 cells after 5 days by MTT assay
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[PMID: 19595598] |
| LoVo | IC50 |
17 μM
Compound: 2
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Antitumor activity against human LoVo cells after 5 days by MTT assay
Antitumor activity against human LoVo cells after 5 days by MTT assay
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[PMID: 19595598] |
| MCF7 | IC50 |
23 μM
Compound: 2
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Antitumor activity against human MCF7 cells after 5 days by MTT assay
Antitumor activity against human MCF7 cells after 5 days by MTT assay
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[PMID: 19595598] |
| PC-3 | IC50 |
8 μM
Compound: 2
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Antitumor activity against human PC3 cells after 5 days by MTT assay
Antitumor activity against human PC3 cells after 5 days by MTT assay
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[PMID: 19595598] |
| U-373MG ATCC | IC50 |
4 μM
Compound: 2
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Antitumor activity against human U373MG cells after 5 days by MTT assay
Antitumor activity against human U373MG cells after 5 days by MTT assay
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[PMID: 19595598] |
Anticancer agent 118 (Compound 3) (0-100 μΜ; 72 hours) shows high antiproliferative activities against prostate PC3 cells and induces apoptosis/necrosis in PC3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Prostate PC3 and HaCaT cells
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Concentration:0-100 μΜ
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Incubation Time:72 hours
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Result:Showed high antiproliferative activities against prostate PC3 cells with an IC50 of 2.02 μM.
Reduced the growth and proliferation rates in prostate PC3cells, without acytotoxic action against normal HaCaT cell lines.
Induced apoptosis/necrosis in PC3 cells by increasing the intracellular ROS amount and diminished the IL-6 level in tumor cells.
化学情報
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CAS 番号 864443-43-6
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分子量 407.82
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分子式 C19H19ClFN3O4
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SMILES
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(CCl)=O)CC4)=C3)C1=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 118 関連分類
HY-154861 関連分類
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