Anticancer agent 135
Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2957914-60-0
- 分子式: C23H21F3N4OS
- 分子量:458.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
>50 μM
Compound: 26h
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Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 37209451] |
| LNCaP | IC50 |
3.5 μM
Compound: 26h
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Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 37209451] |
化学情報
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CAS 番号 2957914-60-0
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分子量 458.50
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分子式 C23H21F3N4OS
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SMILES
FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 135 関連分類
HY-155543 関連分類
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