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製品番号: HY-139860

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Anticancer agent 15

Anticancer agent 15 is capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2710312-73-3
分子式: C₃₅H₄₀Cl₂N₂O₅
分子量:639.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 15 構造式

CAS 番号: 2710312-73-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Anticancer agent 15 is capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis.

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	5.057 μM Compound: 37	Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
A-375	IC₅₀	4336 μM Compound: 37	Cytotoxicity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
B16-F10	IC₅₀	2.901 μM Compound: 37	Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
CT26	IC₅₀	8.01 μM Compound: 37	Cytotoxicity against mouse CT26 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse CT26 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
HCT-116	IC₅₀	3.263 μM Compound: 37	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
Kasumi 1	IC₅₀	1.921 μM Compound: 37	Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]

化学情報

CAS 番号 2710312-73-3
分子量 639.61
分子式 C₃₅H₄₀Cl₂N₂O₅
SMILES

C[C@@H]([C@@H]([C@]1(C)C=C)OC(C2=CC(Cl)=NC(C)=C2)=O)[C@@](CC3=C)(CC[C@H]4C)[C@](C3=O)([H])[C@@]4([C@@H](C1)OC(C5=CC(Cl)=NC(C)=C5)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang K, et al. A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J Med Chem. 2021 Nov 11;64(21):15825-15845. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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