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製品番号: HY-143303

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Anticancer agent 32

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2222930-76-7
分子式: C₂₄H₂₁F₂N₅O
分子量:433.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 32 構造式

CAS 番号: 2222930-76-7

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)^[1]

体外実験

Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines^[1].
Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca²⁺ and ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
Concentration:

2.5, 5, 10, 20 and 40 μM
Incubation Time:

48 hours
Result:

Inhibited cell growth with IC₅₀ values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

0, 8 and 12 μM
Incubation Time:

24 hours
Result:

Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.

Western Blot Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

4, 8 and 12 μM
Incubation Time:

24 hours
Result:

Decreased expression level of cyclin B1.

Apoptosis Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

0, 4, 8 and 16 μM
Incubation Time:

24 hours
Result:

Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.

化学情報

CAS 番号 2222930-76-7
分子量 433.45
分子式 C₂₄H₂₁F₂N₅O
SMILES

CC1=CC(C)=CC(NC(NC2=CC=CC(CNC3=NC4=CC(F)=C(C=C4N=C3)F)=C2)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li GZ, et al. Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents. Med Chem Res 30, 1496–1511 (2021).

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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