Anticancer agent 322
Anticancer agent 322 is a spirocyclohexane-chroman-4-one derivative. Anticancer agent 322 induces apoptosis and G1 cell cycle arrest in breast cancer cells. Anticancer agent 322 can be used for the research of breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C24H26ClNO6
- 分子量:459.92
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Anticancer agent 322 (Compound 42) potently inhibits MCF7 breast cancer cell viability with an IC50 of 3.9 μM, while being 9.99-fold and 8.95-fold less cytotoxic to noncancerous MCF10A and VA13 cells, respectively, and moderately cytotoxic to MDAMB231 breast cancer cells[1].
Anticancer agent 322 (20 μM; 24 h) induces G1-phase cell cycle arrest and slight apoptosis in MCF7 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 breast cancer cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Induced a G1-phase cell cycle arrest in MCF7 cells, as shown by an increased percentage of cells in G1 phase relative to untreated controls.
Observed a slight but notable level of apoptosis in cell death analysis.
化学情報
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分子量 459.92
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分子式 C24H26ClNO6
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SMILES
ClC(C=C1)=CC=C1NC(COC2=CC=C3C(OC4(CCC5(OCCO5)CC4)CC3O)=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 322 関連分類
HY-183587 関連分類
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