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United States

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製品番号: HY-189125

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Anticancer agent 360

Anticancer agent 360 is a broad-spectrum antibacterial agent. Anticancer agent 360 binds to the ATP pocket of the GyrB subunit of DNA gyrase via an Arg84 salt bridge, interfering with gyrase-dependent DNA supercoiling. Anticancer agent 360 disrupts bacterial biofilms and inhibits the metabolic activity of respiratory chain dehydrogenases. Anticancer agent 360 exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and fungal strains. Anticancer agent 360 exerts selective cytotoxicity against liver cancer cells. Anticancer agent 360 can be used in studies related to bacterial infections and liver cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₁₃N₃O₅
分子量:411.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 360 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

Bacterial InfectionFungal InfectionAnti-cancer

Bacterial Infection

Fungal Infection

Anticancer agent 360 (compound 13) (2-64 µg/mL; 24-30 h) exhibits potent and broad-spectrum antimicrobial activity against all tested reference bacterial and fungal strains, with its MIC against Staphylococcus aureus ATCC 9144 as low as 2 µg/mL^[1].

Anti-cancer

Anticancer agent 360 (5-100 µg/mL; 48 h) reduces the viability of HepG2 cells at high concentrations, exhibiting selective cytotoxic activity against HepG2 hepatocellular carcinoma cells^[1].

Bacterial Infection

Anticancer agent 360 (0.25-0.8 MIC; 2-4 h) eliminates preformed P. aeruginosa ATCC 27853 biofilms in a dose- and time-dependent manner^[1].
Antineoplastic agent 360 (0.25-0.8 MIC; 2-4 h) effectively inhibits the activity of respiratory chain dehydrogenase in P. aeruginosa ATCC 27853 biofilms, and this effect exhibits a concentration- and time-dependent manner in vitro^[1].
Anticancer agent 360 exhibits strong binding affinity for the ATP-binding pockets of DNA gyrase from both E. coli and S. aureus, and can form stable salt bridge interactions with key active-site residues, with its relative affinity for the S. aureus enzyme being higher than that of the co-crystallized ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human hepatocellular carcinoma HepG2 cells
Concentration:

5 and 100 µg/mL
Incubation Time:

48 h
Result:

Reduced HepG2 cell viability to 85% at 5 µg/mL.
Reduced HepG2 cell viability to 40% at 100 µg/mL.

Related Protocols :

化学情報

分子量 411.37
分子式 C₂₃H₁₃N₃O₅
SMILES

O=C1OC(C2=CC=CC=C2)=NC3=C1C(C4=CC=CO4)=CC(C5=CC=C([N+]([O-])=O)C=C5)=N3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hassan AMA, et al. Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents. Scientific reports. 2026 Aug 08;16(1):24543.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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