Anticancer agent 47
Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2461795-23-1
- 分子式: C19H14N2O4S
- 分子量:366.39
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.72 μM
Compound: 4j
|
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
|
[PMID: 32682198] |
| A549 | IC50 |
4.55 μM
Compound: 4j
|
Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
|
[PMID: 32682198] |
| HepG2 | IC50 |
1.6 μM
Compound: 4j
|
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
|
[PMID: 32682198] |
| L02 | IC50 |
20.98 μM
Compound: 4j
|
Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
|
[PMID: 32682198] |
| NCI-H596 | IC50 |
7.07 μM
Compound: 4j
|
Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
|
[PMID: 32682198] |
Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1].
Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1].
Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2, H596 cells
-
Concentration:0.8, 1.6, 3.2 µM
-
Incubation Time:24 h
-
Result:Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively.
-
Cell Line:HepG2 cells
-
Concentration:0.8, 1.6, 3.2 µM
-
Incubation Time:24 h
-
Result:Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice (HepG2 xenografts)[1]
-
Dosage:20 mg/kg
-
Administration:I.v.; once every 2 days for 19 days
-
Result:Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.
化学情報
-
CAS 番号 2461795-23-1
-
分子量 366.39
-
分子式 C19H14N2O4S
-
SMILES
O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)C4=CC=C(OC)C=C4C1=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 47 関連分類
HY-146040 関連分類
Powered by Bioz