Apoptosis inducer 41
Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer.
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- CAS 番号: 3085940-57-1
- 分子式: C39H53BrN4O4
- 分子量:721.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) exhibits antiproliferative activities in various cells with IC50s of 7.1, 40.9, 6.2 and 46.1 against MDA-MB-231, MDA-MB-468, MCF-7 and MCF-10A cells[1].
Apoptosis inducer 41 (1-9 μM, 24-48 h) significantly induces MCF-7 apoptosis through the mitochondrial apoptosis pathway and arrests cells in the G2/M phase[1].
Apoptosis inducer 41 (1-9 μM, 24 h) induces ROS generation and impaires mitochondrial membrane potential (MMP)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Promoted the G2/M phase block in a concentration-dependent manner.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.
化学情報
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CAS 番号 3085940-57-1
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分子量 721.77
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分子式 C39H53BrN4O4
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SMILES
C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 41 関連分類
HY-175567 関連分類
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