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United States

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製品番号: HY-P10487

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APP669-711

APP669-711 is an N-terminally extended amyloid β peptide (Aβ (-3)-40) that forms amyloid fibrils and co-deposits with Aβ in brain plaques, and also serves as a plasma biomarker for assessing brain Aβ load. APP669-711 can be used in research on Alzheimer's disease.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₁₀H₃₂₅N₅₇O₆₁S₂
分子量:4688.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

APP669-711 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

APP669-711 is produced in HEK293A cells by APPwt and c102 in a DAPT-sensitive manner, is upregulated by ADAMTS4, and is abolished by the Swedish mutation^[1].
APP669-711 production in HEK293A cells is enhanced to a greater extent by ADAMTS5 co-expression than by ADAMTS4, requires the ADAMTS5 Sp domain, and is abolished by the E411A catalytic mutation or an ADAMTS5 inhibitor; exogenous ADAMTS5 conditioned medium does not significantly increase APP669-711^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

分子量 4688.30
分子式 C₂₁₀H₃₂₅N₅₇O₆₁S₂
配列

Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
シーケンスの短縮

VKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (300 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Matsuzaki M, et al. ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. Molecular psychiatry. 2023 Apr;28(4):1802-1812.

[2]. Kaneko N, et al. Novel plasma biomarker surrogating cerebral amyloid deposition. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2014;90(9):353-64.

[3]. Yokoyama M, et al. Identification of ADAMTS5 as APP-Cleaving Enzyme at the APP669 Site. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2026 Apr 15;40(7):e71701.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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