Arcopilin A
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H27NO4
- 分子量:369.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB 3-1 | IC50 |
8.9 μg/mL
Compound: 1; Acp A
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Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
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[PMID: 39141525] |
| L929 | IC50 |
14 μg/mL
Compound: 1; Acp A
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Cytotoxicity against mouse L929 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
Cytotoxicity against mouse L929 cells assessed as inhibition of cell growth incubated for 5 days by MTT assay
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[PMID: 39141525] |
Arcopilin A disruptes preformed biofilms by approximately 50-60% in the concentration range of 15.6-250 μg/mL, and can also inhibit the growth of Staphylococcus aureus at concentrations as low as 3.9 and 7.8 μg/mL[1].
Arcopilin A has an MIC value of 66.7 μg/mL against B.subtilis DSM 10, S.aureus DSM 346, S.pombe DSM70572, C.albicans DSM 1665, and M.hiemalis DSM 2656, and an MIC value of 31.3 μg/mL against S.aureus DSM 1104[1].
Arcopilin A (3.9-31.1 μg/mL) reduces biofilm metabolic activity in a dose-dependent manner[1].
Arcopilin A (2-7.8 μg/mL) inhibits the growth of Staphylococcus aureus DSM 1104 planktonic cells[1].
Arcopilin A (3.9-7.8 μg/mL, 24 h) when used with GM (HY-K1050) and Vac (HY-B0671) have a synergistic effect on Staphylococcus aureus DSM 1104 planktonic cells. The MIC values of the established antibiotics were reduced from 15.6 to 0.13 μg/mL and from 2 to 0.065 μg/mL respectively. The combined treatment significantly increased the potency of GM (HY-K1050) and Vac (HY-B0671) by 115-fold and 31-fold, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 369.45
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分子式 C22H27NO4
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SMILES
CC([C@@H](C[C@H](C[C@@H](C(C1=C(/C(NC1=O)=C/C2=CC=CC=C2)O)=O)C)C)C)=O
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Structure Classification
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Initial Source
Arcopilus navicularis CCF 3252T
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Arcopilin A 関連分類
HY-N13196 関連分類
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