Artonin E
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 129683-93-8
- 分子式: C25H24O7
- 分子量:436.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 1A9 | ED50 |
<1.25 μg/mL
Compound: 12
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Cytotoxicity against human 1A9 cells
Cytotoxicity against human 1A9 cells
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[PMID: 15165133] |
| A549 | ED50 |
8.5 μg/mL
Compound: 12
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 15165133] |
| CAKI-1 | ED50 |
9.7 μg/mL
Compound: 12
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Cytotoxicity against human Caki1 cells
Cytotoxicity against human Caki1 cells
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[PMID: 15165133] |
| HCT-8 | ED50 |
3.3 μg/mL
Compound: 12
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Cytotoxicity against human HCT8 cells
Cytotoxicity against human HCT8 cells
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[PMID: 15165133] |
| KB | ED50 |
6.5 μg/mL
Compound: 12
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 15165133] |
| MCF7 | ED50 |
2.2 μg/mL
Compound: 12
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 15165133] |
| MDA-MB-231 | ED50 |
3 μg/mL
Compound: 12
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Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
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[PMID: 15165133] |
| P388 | IC50 |
0.14 μM
Compound: 9
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Antiproliferative activity against mouse P388 cells assessed as reduction in cell viability
Antiproliferative activity against mouse P388 cells assessed as reduction in cell viability
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[PMID: 30830783] |
| PC-3 | ED50 |
6.9 μg/mL
Compound: 12
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Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
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[PMID: 15165133] |
| SK-MEL-2 | ED50 |
4.3 μg/mL
Compound: 12
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Cytotoxicity against human SK-MEL-2 cells
Cytotoxicity against human SK-MEL-2 cells
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[PMID: 15165133] |
| U-87MG ATCC | ED50 |
6.4 μg/mL
Compound: 12
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Cytotoxicity against human U87MG cells
Cytotoxicity against human U87MG cells
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[PMID: 15165133] |
Artonin E (0-100 μg/mL, 24-72 h) acts on SKOV-3 cells, T1074 cells, human periodontal ligament fibroblasts and CHO cells with the IC50 values of 12.83, 44.8, 67 and 57.6 μg/mL, respectively . And it can reduce the cell viability of SKOV-3 cells in a time-dependent manner[1].
Artonin E(0-20 μg/mL, 24 h) can inhibit the colony formation of SKOV-3 cells in a dose-dependent manner. At 5 μg/mL, almost half of the colonies were reduced. When using 15 and 20 μg/mL, No colonies formed[1].
Artonin E (8 μg/mL, 24-72 h) can induce the depletion of SKOV-3 cells in S phase, and at 72 h, the accumulation of cells arrested in S phase was significantly increased, while the ratio of cells in G0/G1 phase decreased[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKOV-3 cell lines
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Concentration:8 μg/mL
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Incubation Time:24, 48, 72 h
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Result:Induced ROS formation.
Induced disruption of mitochondrial membrane potential and release of cytochrome c.
Significantly upregulated the protein expression levels of caspase-9 and -3,up-regulated Bax and inhibited the expression of Bcl-2, HSP70 and survivin.
化学情報
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CAS 番号 129683-93-8
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分子量 436.45
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分子式 C25H24O7
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SMILES
O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC(C4=CC(O)=C(O)C=C4O)=C1C/C=C(C)\C
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別名
5'-Hydroxymorusin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Artonin E 関連分類
HY-125612 関連分類
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