Asundexian
Based on 5 publication(s) in Google Scholar
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 2064121-65-7
- 分子式: C26H21ClF4N6O4
- 分子量:592.93
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 2064121-65-7
-
性状 Solid
-
分子量 592.93
-
分子式 C26H21ClF4N6O4
-
Color White to off-white
-
SMILES
COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C=C4)C(N)=O)=O)C3=O
-
別名
BAY-2433334
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
J Thromb Haemost
Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents. [Abstract]2025 Jun 9:S1538-7836(25)00354-X. PMID: 40499719 -
Diagnostics (Basel)
Laboratory Evaluation of Interferences Associated with Factor XIa Inhibitors Asundexian and Milvexian in Routine Coagulation Assays. [Abstract]2024 Sep 9;14(17):1991. PMID: 39272775 -
Front Biosci (Landmark Ed)
Inhibition of Activated Coagulation Factor XII by the Phosphodiesterase-4 Inhibitor Roflumilast: In Vitro and In Silico Studies. [Abstract]2025 May 21;30(5):38395. PMID: 40464522 -
-
溶剤 & 溶解度
DMSO : ≥ 250 mg/mL (421.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6865 mL | 8.4327 mL | 16.8654 mL | 42.1635 mL |
| 5 mM | 0.3373 mL | 1.6865 mL | 3.3731 mL | 8.4327 mL | |
| 10 mM | 0.1687 mL | 0.8433 mL | 1.6865 mL | 4.2163 mL | |
| 15 mM | 0.1124 mL | 0.5622 mL | 1.1244 mL | 2.8109 mL | |
| 20 mM | 0.0843 mL | 0.4216 mL | 0.8433 mL | 2.1082 mL | |
| 25 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6865 mL | |
| 30 mM | 0.0562 mL | 0.2811 mL | 0.5622 mL | 1.4054 mL | |
| 40 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0541 mL | |
| 50 mM | 0.0337 mL | 0.1687 mL | 0.3373 mL | 0.8433 mL | |
| 60 mM | 0.0281 mL | 0.1405 mL | 0.2811 mL | 0.7027 mL | |
| 80 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5270 mL | |
| 100 mM | 0.0169 mL | 0.0843 mL | 0.1687 mL | 0.4216 mL |
Asundexian 関連分類
HY-137431 関連分類
Powered by Bioz