Atromentin
Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective enoyl-ACP reductase FabK inhibitor with an IC50 of 0.24 μM. Atromentin exhibits selectivity over FabI. Atromentin can be used for antimicrobial research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 519-67-5
- 分子式: C18H12O6
- 分子量:324.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
5.71 μM
Compound: 7
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 36126897] |
化学情報
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CAS 番号 519-67-5
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分子量 324.29
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分子式 C18H12O6
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SMILES
O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3
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Structure Classification
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Initial Source
fungus F010248
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Zheng CJ, et al. Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae. J Antibiot (Tokyo). 2006 Dec;59(12):808-12. [Content Brief]
[2]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Atromentin 関連分類
HY-165368 関連分類
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