country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-183076

Copy Link Print Information

AW00718

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 215778-00-0
分子式: C₁₇H₁₃BrN₄S
分子量:385.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AW00718 構造式

CAS 番号: 215778-00-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AW00718 forms a stable complex with homology-modelled Brachyspira pilosicoli glutamate racemase (Bp-MurI)^[1].
AW00718 (5 days) inhibits the growth of Brachyspira pilosicoli strain BP2904 in vitro with a MIC₅₀ of 0.25 mM and a MIC₁₀₀ of 0.5 mM^[1].
AW00718 (1 mM; 24 h) causes ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 24 hours of treatment and 6 hours of Resazurin (HY-118540) exposure, with no cytotoxicity detected after 24 hours of Resazurin exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human Chang conjunctival epithelial cells
Concentration:

1 mM
Incubation Time:

24 h following6 h (Resazurin exposure); 24 h (Resazurin exposure single)
Result:

Induced ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 6 hours of Resazurin exposure.
Caused 0% cytotoxicity after 24 hours of resazurin single exposure.

化学情報

CAS 番号 215778-00-0
分子量 385.28
分子式 C₁₇H₁₃BrN₄S
SMILES

BrC1=CC=C(NC2=C3N=NC(SCC4=CC=C(C)C=C4)=N2)C3=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kant R, et al. Identification of small molecule inhibitors for the Brachyspira pilosicoli glutamate racemase (Bp-MurI) enzyme using a computational and experimental approach. Sci Rep. 2026 Apr 2. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

お問い合わせ在庫あり