BAY 3389934
BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and an IC50 of 0.66 nM for factor Xa. BAY 3389934 directly inhibits the activities of factor IIa and factor Xa and regulates the common coagulation pathway. BAY 3389934 exhibits anticoagulant and organ-protective effects. BAY 3389934 can be used in the research of sepsis and coagulopathy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2915316-40-2
- 分子式: C26H30ClN5O7S2
- 分子量:624.13
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
BAY 3389934 (1 mg/L; 5 h) metabolizes rapidly in rat plasma, shows moderate stability in rabbit, miniature pig and dog plasma, and exhibits the highest stability in human plasma[1].
BAY 3389934 exhibits high hepatic clearance in rats, moderate clearance in dogs, and low clearance in human hepatocytes, and shows moderate plasma protein binding across different species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White rabbit (Female)[1]
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Dosage:0.1, 0.3, 1, 3 mg/kg/h
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Administration:i.v.; continuous infusion
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Result:Produced significant, dose-dependent antithrombotic efficacy starting at 0.1 mg/kg/h, as measured by reduced thrombus weight.
Resulted in shorter ear bleeding times than unfractionated heparin at doses with comparable antithrombotic effects.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2915316-40-2
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分子量 624.13
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分子式 C26H30ClN5O7S2
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SMILES
CN1C=CN=C1CCOC([C@@H](NS(C2=C(CC)C(N3C([C@@H](O)CC3)=O)=CC=C2)(=O)=O)CNC(C4=CC=C(Cl)S4)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BAY 3389934 関連分類
HY-172316 関連分類
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