BCP-T.A
Based on 1 Customer Validation
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: ≥99.0%
- CAS 番号: 2786829-70-5
- 分子式: C23H19Cl2N3OS
- 分子量:456.39
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GPX4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
>1 μM
Compound: BCP-TA
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| HeLa | IC50 |
0.242 μM
Compound: BCP-TA
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| HT-1080 | IC50 |
0.019 μM
Compound: BCP-TA
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Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| MDA-MB-231 | IC50 |
0.021 μM
Compound: BCP-TA
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| MDA-MB-468 | IC50 |
0.084 μM
Compound: BCP-TA
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Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| MEF | IC50 |
0.01 μM
Compound: BCP-TA
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Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| NCI-H522 | IC50 |
0.017 μM
Compound: BCP-TA
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Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| NCI-H522 | IC50 |
7.894 μM
Compound: BCP-TA
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Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days in presence of ferroptosis inhibitor, liproxstatin-1 by methylene blue staining based analysis
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days in presence of ferroptosis inhibitor, liproxstatin-1 by methylene blue staining based analysis
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[PMID: 35984756] |
| U2OS | IC50 |
0.367 μM
Compound: BCP-TA
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
| WI-38 | IC50 |
0.022 μM
Compound: BCP-TA
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
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[PMID: 35984756] |
BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM[1].
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2786829-70-5
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性状 Solid
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分子量 456.39
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分子式 C23H19Cl2N3OS
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Color White to light yellow
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SMILES
O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=CSC(C#C)=N4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (267 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BCP-T.A 関連分類
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