BGC1614
BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an KD of 3.859 × 10-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C387H582N94O104S7
- 分子量:8439.78
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PC-3 or N87 cells were implanted into nude mice[1]
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Dosage:1.0, 3.0 mg/kg
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Administration:i.v., once a week, 21 days
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Result:Achieved tumor growth inhibition (TGI) rates of 96.3% in nude mice bearing PC-3 tumor xenografts.
Achieved tumor growth inhibition (TGI) rates of 41.9% and 70.1% respectively in nude mice bearing N87 tumor xenografts.
Showed no significant changes in body weight.
化学情報
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分子量 8439.78
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分子式 C387H582N94O104S7
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配列
Mpa-Pro-Nal-(DAsp)-Cys-Met-hArg-Asp-Trp-Ser-Thr-Pro-HyP-Trp-Cys(TATA covalent with Mpa1,Cys5,Cys15)-Sar10-PEG6-Lys(Lys(N3)-(DBCO-PEG6-βAla-Sar10-Ala-hArg-Asp-Cys-Hyp-Leu-Val-Asn-Pro-Leu-Cys-Leu-His-Pro-(DAsp)-Trp-hArg-Cysteamine, TATA covalent with Cys15,Cys22,Cysteamine 29)-GA-Val-Cit-PABC-MMAE
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BGC1614 関連分類
HY-178489 関連分類
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