Dimethylglyoxime
Based on 1 Customer Validation
Dimethylglyoxime (Biacetyl dioxime) is an oxime compound. Dimethylglyoxime selectively coordinates with divalent nickel ions Ni2+ to form stable complexes, and can also coordinate with copper ions Cu2+, but does not coordinate with iron, selenium or zinc. Dimethylglyoxime inhibits the aggregation of human β-amyloid 40 peptide in vitro. Dimethylglyoxime is used in the research of Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 95-45-4
- 分子式: C4H8N2O2
- 分子量:116.12
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Dimethylglyoxime (Biacetyl dioxime) (100-1000 μM; 60 min) dose-dependently inhibits aggregation of human recombinant amyloid beta 40 peptide in vitro, with full inhibition achieved at 500 μM and 1000 μM in the absence of supplemented metals or presence of 100 μM Ni2+, partial inhibition in the presence of Cu2+, and minimal to no inhibition in the presence of Zn2+[1].
Dimethylglyoxime (1 mM; 5 min per injection) does not directly bind to human recombinant amyloid beta 40 peptide, confirming its inhibitory effect on aggregation is mediated via metal chelation rather than direct peptide interaction[1].
Dimethylglyoxime coordinates with nickel and copper ions to form stable complexes in aqueous solution, but does not form detectable complexes with iron, selenium, or zinc ions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6[1]
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Dosage:6.1 mg
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Administration:p.o.; daily; 3 days
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Result:Was not detected in mouse brain samples via FTICR-MS or NMR analysis.
化学情報
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CAS 番号 95-45-4
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性状 Solid
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分子量 116.12
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分子式 C4H8N2O2
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Color White to off-white
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SMILES
CC(/C(C)=N/O)=N\O
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別名
Biacetyl dioxime
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (861.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (605 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.6118 mL | 43.0589 mL | 86.1178 mL | 215.2945 mL |
| 5 mM | 1.7224 mL | 8.6118 mL | 17.2236 mL | 43.0589 mL | |
| 10 mM | 0.8612 mL | 4.3059 mL | 8.6118 mL | 21.5295 mL | |
| 15 mM | 0.5741 mL | 2.8706 mL | 5.7412 mL | 14.3530 mL | |
| 20 mM | 0.4306 mL | 2.1529 mL | 4.3059 mL | 10.7647 mL | |
| 25 mM | 0.3445 mL | 1.7224 mL | 3.4447 mL | 8.6118 mL | |
| 30 mM | 0.2871 mL | 1.4353 mL | 2.8706 mL | 7.1765 mL | |
| 40 mM | 0.2153 mL | 1.0765 mL | 2.1529 mL | 5.3824 mL | |
| 50 mM | 0.1722 mL | 0.8612 mL | 1.7224 mL | 4.3059 mL | |
| 60 mM | 0.1435 mL | 0.7176 mL | 1.4353 mL | 3.5882 mL | |
| 80 mM | 0.1076 mL | 0.5382 mL | 1.0765 mL | 2.6912 mL | |
| 100 mM | 0.0861 mL | 0.4306 mL | 0.8612 mL | 2.1529 mL |
Dimethylglyoxime 関連分類
HY-W012898 関連分類
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