BNTX
BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ1 opioid receptors, and does not alter the antinociceptive effects mediated by δ2, μ or κ opioid receptors at selective doses.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 129468-28-6
- 分子式: C27H27NO4
- 分子量:429.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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δ Opioid Receptor/DOR |
BNTX is highly selective for δ1 opioid receptors in guinea pig brain membranes, with 100-fold greater affinity for δ1 versus δ2 sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ND4 Swiss-Webster (male, 20-25 g)[1]
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Dosage:1.3 μmol/kg (s.c. pretreatment); 1 pmole/mouse (i.t. pretreatment)
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Administration:s.c.; single dose, 30 minutes prior to agonist assay; i.t.; single dose, 10 minutes prior to agonist assay
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Result:Increased the antinociceptive ED50 of δ1 agonist DPDPE (i.t.) from 6.3 to 36.1 nmol/mouse at 1.3 μmol/kg s.c. dose.
Did not significantly alter the antinociceptive ED50 of δ2 agonist DELT II (i.t.), μ agonists DAMGO and morphine (i.t.), or κ agonist U-50,488H (i.t.), at 1.3 μmol/kg s.c. dose.
Increased the antinociceptive ED50 of DPDPE (i.t.) from 6.3 to 25.5 nmol/mouse at 1 pmole/mouse i.t. dose.
Did not significantly alter the antinociceptive ED50 of DELT II (i.t.), μ agonist DAMGO (i.t.), or κ agonist U-50,488H (i.t.), at 1 pmole/mouse i.t. dose.
化学情報
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CAS 番号 129468-28-6
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分子量 429.51
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分子式 C27H27NO4
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SMILES
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(/C(C1)=C\C7=CC=CC=C7)=O
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別名
7-Benzylidenenaltrexone
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BNTX 関連分類
HY-169867 関連分類
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