BNTX
BNTX (7-Benzylidenenaltrexone) is a highly selective δ1 opioid receptor antagonist. BNTX selectively antagonizes the antinociceptive activity mediated by spinal δ1 opioid receptors, and does not alter the antinociceptive effects mediated by δ2, μ or κ opioid receptors at selective doses.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 129468-28-6
- 分子式: C27H27NO4
- 分子量:429.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
δ Opioid Receptor/DOR |
体外実験
BNTX is highly selective for δ1 opioid receptors in guinea pig brain membranes, with 100-fold greater affinity for δ1 versus δ2 sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ND4 Swiss-Webster (male, 20-25 g)[1]
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Dosage:1.3 μmol/kg (s.c. pretreatment); 1 pmole/mouse (i.t. pretreatment)
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Administration:s.c.; single dose, 30 minutes prior to agonist assay; i.t.; single dose, 10 minutes prior to agonist assay
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Result:Increased the antinociceptive ED50 of δ1 agonist DPDPE (i.t.) from 6.3 to 36.1 nmol/mouse at 1.3 μmol/kg s.c. dose.
Did not significantly alter the antinociceptive ED50 of δ2 agonist DELT II (i.t.), μ agonists DAMGO and morphine (i.t.), or κ agonist U-50,488H (i.t.), at 1.3 μmol/kg s.c. dose.
Increased the antinociceptive ED50 of DPDPE (i.t.) from 6.3 to 25.5 nmol/mouse at 1 pmole/mouse i.t. dose.
Did not significantly alter the antinociceptive ED50 of DELT II (i.t.), μ agonist DAMGO (i.t.), or κ agonist U-50,488H (i.t.), at 1 pmole/mouse i.t. dose.
化学情報
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CAS 番号 129468-28-6
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分子量 429.51
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分子式 C27H27NO4
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SMILES
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(/C(C1)=C\C7=CC=CC=C7)=O
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別名
7-Benzylidenenaltrexone
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BNTX 関連分類
HY-169867 関連分類
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