BPH-1086
BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1226901-43-4
- 分子式: C4H8O7P2
- 分子量:230.05
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
Target: IspH[1]
体外実験
IspH (LytB) is the last enzyme in the nonmevalonate pathway, IspH domains can be fused to either the ribosomal protein S1 (RPS1), IspH–RPS1 binds to mRNA or forms part of the bacterial ribosome[1][2].
IspH–RPS1 proteins are present in anaerobes found in the human gut and some, such as Clostridium botulinum, C. tetani and Fusobacterium nucleatum, are pathogens[2].
IspH inhibitor will therefore kill bacteria directly, as with other antibiotics, but will also kill persistent bacteria by microptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1226901-43-4
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分子量 230.05
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分子式 C4H8O7P2
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SMILES
O=P(O)(OP(O)(O)=O)OCC#CC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
純度とドキュメンテーション
参考文献
[1]. Wang W, et al. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. [Content Brief]
[2]. Rao G, et al. IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins. Chem Sci. 2015 Dec 1;6(12):6813-6822. [Content Brief]
[3]. Singh KS, et al. IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance. Nature. 2021 Jan. 589(7843):597-602. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BPH-1086 関連分類
HY-147304 関連分類
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