BPIPP
Based on 1 Customer Validation
BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.3%
- CAS 番号: 325746-94-9
- 分子式: C22H16BrN3O3
- 分子量:450.28
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| T84 | IC50 |
3.4 μM
Compound: 1, BPIPP
|
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
|
[PMID: 19409779] |
| T84 | IC50 |
9.6 μM
Compound: 1, BPIPP
|
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
|
[PMID: 19409779] |
BPIPP suppresses stable toxin (STa)-stimulated cGMP accumulation by decreasing GC-C activation in intact T84 human colorectal carcinoma cells. BPIPP inhibits stimulation of guanylyl cyclases, including types A and B and soluble isoform in various cells. BPIPP suppresses stimulation of adenylyl cyclase and significantly decreases the activities of adenylyl cyclase toxin of Bordetella pertussis and edema toxin of Bacillus anthracis. The effects of BPIPP on cyclic nucleotide synthesis were observed only in intact cells[1].
BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases and suppressed STa-induced fluid accumulation in an in vivo rabbit intestinal loop model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 325746-94-9
-
性状 Solid
-
分子量 450.28
-
分子式 C22H16BrN3O3
-
Color Orange to red
-
SMILES
O=C1C2=C(C3=CC=CC=C13)NC(N(C(N(C)C4=O)=O)C)=C4C2C5=CC(Br)=CC=C5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (271 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BPIPP 関連分類
HY-107547 関連分類
Powered by Bioz