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United States

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製品番号: HY-161938

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BRD8518

BRD8518 is a PCSK9 inhibitor (EC₅₀=0.23 μM). BRD8518 lowers blood lipids by upregulating LDLR expression and stimulating LDL uptake. BRD8518 can be used in the study of cardiovascular diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1565828-01-4
分子式: C₃₃H₃₂F₃N₃O₅
分子量:607.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRD8518 構造式

CAS 番号: 1565828-01-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	0.23 μM Compound: 1; BRD8518	Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.24 μM Compound: 1; BRD8518	Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.36 μM Compound: 77	Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis	[PMID: 30448414]
HepG2	EC₅₀	0.43 μM Compound: 1; BRD8518	Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.49 μM Compound: 1; BRD8518	Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]

化学情報

CAS 番号 1565828-01-4
分子量 607.62
分子式 C₃₃H₃₂F₃N₃O₅
SMILES

O=C(NC1=CC=C2C(C(N(C)[C@H]3CC[C@@H](CC(NC4CC(C=CC=C5)=C5C4)=O)O[C@H]3CO2)=O)=C1)C6=CC=C(C(F)(F)F)C=C6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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