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製品番号: HY-16117A

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Brostallicin

Name: Brostallicin
Brand: MedChemExpress
SKU: HY-16117A
Availability: PreOrder

(別名: PNU-166196)

Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 203258-38-2
分子式: C₃₀H₃₆BrClN₁₂O₅
分子量:760.04

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Brostallicin 構造式

CAS 番号: 203258-38-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.64 nM Compound: 17 (brostallicin)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM) Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)	[PMID: 15115402]
L1210	IC₅₀	1.8 nM Compound: 9	In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure	[PMID: 12031321]
L1210	IC₅₀	1.85 nM Compound: 17 (brostallicin)	In vitro test for cytotoxicity against L1210 murine leukemia cells In vitro test for cytotoxicity against L1210 murine leukemia cells	[PMID: 15115402]
L1210	IC₅₀	2.13 nM Compound: 17 (brostallicin)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells	[PMID: 15115402]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 203258-38-2
分子量 760.04
分子式 C₃₀H₃₆BrClN₁₂O₅
SMILES

O=C(C(Br)=C)NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCNC(N)=N)=O)=C4)=O)=C3)=O)=C2)=O)=C1.Cl
別名

PNU-166196
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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