CAIF
CAIF is an irreversible, selective allosteric covalent inhibitor of ucosyltransferase 8 (FUT8) with an IC50 of 5.7 μM. CAIF inhibits core fucosylation modification in cancer cells, and suppresses the invasion and migration of cancer cells. CAIF is applicable for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H46BrN3O4
- 分子量:556.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
CAIF (0-500 μM; 72 h) exhibits extremely low cytotoxicity in HeLa, A375, GAK and HEK293T cells, with no toxicity detected at the concentration of 500 μM in HeLa and GAK cells[1].
CAIF (0-300 μM; 72 h) significantly inhibits core fucosylation in HeLa, A375 and GAK cells, with an EC50 of 38.4 μM in GAK cells[1].
CAIF (1-100 μM; 72 h) inhibits the invasion of HeLa cells in vitro, and its efficacy is superior to that of 2FF at the tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa
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Concentration:1, 10, 50, 100 μM
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Incubation Time:48 h (pretreatment); 24 h (invasion assay incubation at 37 °C)
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Result:Outperformed 2FF in suppressing HeLa cell migration and invasion in the in vitro invasion assay.
化学情報
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分子量 556.58
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分子式 C27H46BrN3O4
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SMILES
C[N+]1=C(C)N(C=C1)CCCCCCCCCCCCCCCCCC(ON2C(CCC2=O)=O)=O.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CAIF 関連分類
HY-181989 関連分類
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