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製品番号: HY-156789

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CD38-IN-4

CD38-IN-4 is a CD38 inhibitor. CD38-IN-4 inhibits CD38 hydrolase enzymatic activity through mixed inhibition kinetics, binding partially inside and partially outside the NAD⁺ catalytic pocket. CD38-IN-4 acts as a DNA-binding agent. CD38-IN-4 can be used for research on neuroblastoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 524055-93-4
分子式: C₁₈H₂₃N₅
分子量:309.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CD38-IN-4 構造式

CAS 番号: 524055-93-4

価格（税別）

Amount: USD 0.00

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

体外実験

Anti-cancerOthers

Anti-cancer

CD38-IN-4 (compound 2) (72 h) exhibits cytotoxicity against SF767 glioblastoma cells with an LC₅₀ of 2.6 μM^[2].

Others

CD38-IN-4 (compound 13) (50 μM; 15 minutes) inhibits human recombinant CD38 hydrolase activity with an IC₅₀ of 22.4 μM^[1].
CD38-IN-4 (1.0 μM; 24 hours) does not affect the proliferation of SHSY5Y-GFP neuroblastoma cells at 1.0 μM over 24 hours^[1].
CD38-IN-4 (10 μM) binds to calf thymus DNA in the HT-FID assay^[2].
CD38-IN-4 (15-20 μM) binds preferentially to A/T-rich DNA, as indicated by thermal melting studies^[2].
CD38-IN-4 (7.7 μM) is a reasonably strong DNA-binding agent relative to control agents^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 524055-93-4
分子量 309.42
分子式 C₁₈H₂₃N₅
SMILES

N=1C(=NC(=C2C=CC(=CC12)CC)C)NC3=NC(=CC(N3)(C)C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Mills CM, et al. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical science. 2023 Feb 22;14(8):2168-2182.

[2]. Glass LS, et al. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & medicinal chemistry letters. 2010 Mar 01;20(5):1685-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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