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United States

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製品番号: HY-164628

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CD38-IN-5

CD38-IN-5 (compound 1) is a CD38 inhibitor that selectively inhibits CD38 hydrolase with an IC₅₀ of 4.0 μM. CD38-IN-5 does not inhibits CD38 cyclase. CD38-IN-5 is highly effective at promoting NK cell-mediated tumor toxicity. CD38-IN-5 increases NADH+ and IFNγ levels in activated PBMCs. CD38-IN-5 can be used for the study of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 314039-40-2
分子式: C₁₈H₂₃N₅
分子量:309.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CD38-IN-5 構造式

CAS 番号: 314039-40-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-33	IC₅₀	0.8 μM Compound: 11c	Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis	[PMID: 25288188]
CAL-33	IC₅₀	1.2 μM Compound: 11c	Growth inhibition of human CAL33 cells Growth inhibition of human CAL33 cells	[PMID: 25288188]
CAL-33	IC₅₀	5.9 μM Compound: 11c	Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis	[PMID: 25288188]
FaDu	IC₅₀	1.9 μM Compound: 11c	Growth inhibition of human FADU cells Growth inhibition of human FADU cells	[PMID: 25288188]
L6	CC₅₀	10 μM Compound: 5	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19364854]

化学情報

CAS 番号 314039-40-2
分子量 309.41
分子式 C₁₈H₂₃N₅
SMILES

CC1=CC(C)=CC2=C(C)N=C(N=C21)NC3=NC(C)=CC(C)(C)N3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Patrick M. Woster, et al. Selective targeting of cd38 activity as an immunostimulatory and antitumor strategy. WO2023039170A1.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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