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United States

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製品番号: HY-182561

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Cgs 27830

Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 155485-56-6
分子式: C₃₂H₃₀N₄O₁₁
分子量:646.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Cgs 27830 構造式

CAS 番号: 155485-56-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endothelin Receptor アイソフォーム固有の製品をすべて表示 :

ET_A
ET_B

体内実験

CGS 27830 (100 mcg/min; intrapulmonary infusion; 10 min) does not alter basal pulmonary vascular tone in late gestation fetal lambs but completely blocks big-ET-1-induced pulmonary vasoconstriction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Columbia-Rambouillet (mixed breed, late gestation 131 days)^[1]
Dosage:

100 mcg/min
Administration:

intrapulmonary infusion; 10 min
Result:

Did not alter baseline left pulmonary artery flow, mean pulmonary artery pressure, mean aortic pressure, left atrial pressure, pulmonary vascular resistance, heart rate, or blood gas parameters.
Blocked the big-ET-1-induced increase in pulmonary vascular resistance.
Blocked the big-ET-1-induced rise in mean pulmonary artery pressure.
Prevented changes in left pulmonary artery flow.

化学情報

CAS 番号 155485-56-6
分子量 646.60
分子式 C₃₂H₃₀N₄O₁₁
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)OC(C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC([N+]([O-])=O)=CC=C4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ivy DD, et al. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest. 1994;93(5):2141-2148. [Content Brief]

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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