Clamikalant
Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 158751-64-5
- 分子式: C19H22ClN3O5S2
- 分子量:471.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
8.2 μM
Compound: 33 HMR-1883
|
Inhibition of human SUR1/Kir6.2 expressed in CHO cells
Inhibition of human SUR1/Kir6.2 expressed in CHO cells
|
[PMID: 11356099] |
| Oocyte | IC50 |
4.3 μM
Compound: 33 HMR-1883
|
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes
|
[PMID: 11356099] |
化学情報
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CAS 番号 158751-64-5
-
分子量 471.98
-
分子式 C19H22ClN3O5S2
-
SMILES
O=C(NCCC1=CC=C(OC)C(S(=O)(NC(NC)=S)=O)=C1)C2=CC(Cl)=CC=C2OC
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別名
HMR 1098 free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)