Cliramitug
Based on 1 Customer Validation
Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.0%
- CAS 番号: 2965214-50-8
- 分子量:144.542 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
Transthyretin/TTR
体外実験
Cliramitug accelerates phagocyte-mediated clearance of dense-structured ATTR amyloid fibrils in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1X106 A549 cells labeling TTR with Cliramitug (HY-P991128, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
化学情報
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CAS 番号 2965214-50-8
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性状 Liquid
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分子量 144.542 kDa
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Color Colorless to light yellow
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SMILES
[Cliramitug]
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別名
NI-006; ALXN2220
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Keywords
- Cliramitug
- 2965214-50-8
- NI-006
- ALXN2220
- NI006
- NI 006
- ALXN2220
- ALXN 2220
- ALXN-2220
- Transthyretin (TTR)
- TTR monomers
- macrophage-mediated phagocytosis
- TTR amyloid fibrils
- transthyretin cardiac amyloidosis
- patient-derived fibril xenograft mice
- phagocyte-mediated clearance
- ATTR amyloid fibrils
- conformationally exposed peptide epitope
- cardiac amyloid deposits
- TTR tetramers
- Inhibitor
- inhibitor
- inhibit