Clofexamide
Clofexamide (ANP 246) is an orally active antidepressant agent, exhibiting analgesic and anti-inflammatory activity. Clofexamide can be used for the research of depression, inflammatory disorders, peptic ulcer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1223-36-5
- 分子式: C14H21ClN2O2
- 分子量:284.78
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male; 300-400 g, 8-week-old)[2]
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Dosage:200 mg/kg
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Administration:p.o.; single dose
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Result:Excreted approximately 85% of the dosed clofexamide in urine within 24 hours, with 36% as unchanged clofexamide, 20% as 2-(p-chlorophenoxy)-N-(2-ethylaminoethyl) acetamide, 7% as 2-(p-chlorophenoxy)-N-(2-aminoethyl) acetamide, 7% as 2-(4-chloro-2-hydroxyphenoxy)-N-(2-diethylaminoethyl) acetamide, 15% as p-chlorophenoxyacetic acid, plus minor amounts of 2-(p-chlorophenoxy)-N-(2-diethylaminoethyl) acetamide N-oxide and p-chlorophenoxyaceturic acid.
Detected additional urinary metabolites including 2-(4-chloro-3-hydroxyphenoxy)-N-(2-diethylaminoethyl) acetamide, 2-(4-chloro-3-hydroxyphenoxy)-N-(2-ethylaminoethyl) acetamide, 2-(4-chloro-2-hydroxyphenoxy)-N-(2-ethylaminoethyl) acetamide.
Detected only unchanged clofexamide in feces.
化学情報
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CAS 番号 1223-36-5
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分子量 284.78
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分子式 C14H21ClN2O2
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SMILES
CCN(CC)CCNC(COC1=CC=C(Cl)C=C1)=O
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別名
ANP 246; Amichlophene; Chlofexamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kirkpatrick D, et al. Identification of an N-oxide as the major metabolite of the analgesic O-(diethylaminoethyl)-4-chlorobenzaldoxime hydrochloride in dogs. Xenobiotica. 1977 Dec;7(12):747-55. [Content Brief]
[2]. Irino O, et al. Studies on absorption, biotransformation and excretion of drug. 1. Metabolites of clofexamide in rat. Chem Pharm Bull (Tokyo). 1972 Jan;20(1):47-55. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Clofexamide 関連分類
HY-105698 関連分類
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