Clonixeril
Based on 1 Customer Validation
Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTINGWT pathway at low femtomolar (10-15 M) and in some cases even attomolar (10-18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.63%
- CAS 番号: 21829-22-1
- 分子式: C16H17ClN2O4
- 分子量:336.77
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-3898875898
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
化学情報
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CAS 番号 21829-22-1
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性状 Solid
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分子量 336.77
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分子式 C16H17ClN2O4
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Color White to off-white
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SMILES
O=C(C1=CC=CN=C1NC2=C(C)C(Cl)=CC=C2)OCC(CO)O
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別名
NSC 335504
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (296.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9694 mL | 14.8469 mL | 29.6939 mL | 74.2346 mL |
| 5 mM | 0.5939 mL | 2.9694 mL | 5.9388 mL | 14.8469 mL | |
| 10 mM | 0.2969 mL | 1.4847 mL | 2.9694 mL | 7.4235 mL | |
| 15 mM | 0.1980 mL | 0.9898 mL | 1.9796 mL | 4.9490 mL | |
| 20 mM | 0.1485 mL | 0.7423 mL | 1.4847 mL | 3.7117 mL | |
| 25 mM | 0.1188 mL | 0.5939 mL | 1.1878 mL | 2.9694 mL | |
| 30 mM | 0.0990 mL | 0.4949 mL | 0.9898 mL | 2.4745 mL | |
| 40 mM | 0.0742 mL | 0.3712 mL | 0.7423 mL | 1.8559 mL | |
| 50 mM | 0.0594 mL | 0.2969 mL | 0.5939 mL | 1.4847 mL | |
| 60 mM | 0.0495 mL | 0.2474 mL | 0.4949 mL | 1.2372 mL | |
| 80 mM | 0.0371 mL | 0.1856 mL | 0.3712 mL | 0.9279 mL | |
| 100 mM | 0.0297 mL | 0.1485 mL | 0.2969 mL | 0.7423 mL |
Clonixeril 関連分類
HY-171012 関連分類
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