country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-111159

Copy Link Print Information

CP-467688

CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 909576-25-6
分子式: C₂₇H₂₇ClF₃N₃O₃
分子量:533.97

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CP-467688 構造式

CAS 番号: 909576-25-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CP-467688 (1.2-100.0 mM; 24 h) induces concentration-dependent lysosomal volume expansion in ARPE-19 cells^[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits the phagocytic function of ARPE-19 cells^[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits autophagic flux in ARPE-19 cells, with the peak punctate LC3 fluorescence intensity being approximately 5 times that of the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

ARPE-19
Concentration:

1.5, 1.2, 3.1, 3.7, 11.1, 33.3, 100.0 mM
Incubation Time:

24 h
Result:

Induced a concentration-dependent increase in punctate LC3 fluorescence intensity relative to vehicle control, with peak activity reaching approximately 5-fold greater than control.
Triggered a > 2-fold increase in LC3 intensity at multiple tested concentrations.

体内実験

CP-467688 (100-500 mg/kg; p.o.; daily; 7-14 days) induces retinal toxicity in male Sprague-Dawley rats, as evidenced by vacuolization and disruption of the RPE layer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male)^[1]
Dosage:

100 mg/kg; 500 mg/kg
Administration:

p.o.; daily; 7-14 days
Result:

Induced retinal lesions characterized by disrupted retinal pigmented epithelium (RPE) with multiple, round-to-oval vacuoles of variable size in RPE cytoplasm.

化学情報

CAS 番号 909576-25-6
分子量 533.97
分子式 C₂₇H₂₇ClF₃N₃O₃
SMILES

O=C(OC)NCCN1CC2=C(C=C(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)C=C2)CC1.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Khoh-Reiter S, et al. Contribution of membrane trafficking perturbation to retinal toxicity. Toxicol Sci. 2015 Jun;145(2):383-95.
[Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

お問い合わせ在庫あり