CRL-42872
CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 256385-24-7
- 分子式: C22H27ClN6O6S
- 分子量:539.00
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CRL-42872 (1.5×10-8 M - 7×10-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC50 of 9.4×10-8 M[1].
CRL-42872 (10-8 M - 5×10-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC50 of 1.2×10-7 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dunkin-Hartley (male, ~330 g)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.
化学情報
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CAS 番号 256385-24-7
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分子量 539.00
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分子式 C22H27ClN6O6S
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SMILES
O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CRL-42872 関連分類
HY-119238 関連分類
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