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製品番号: HY-122431

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Crufomate

Crufomate is an organophosphate insecticide. Crufomate is used to control warble fly maggot infections and botfly infestations in dairy cows, and accumulates in milk fat. Crufomate reduces mating responses, conception rates, pup survival rates, and post-weaning body weights of offspring in mice. Crufomate is used in studies related to botfly infestations and gastrointestinal parasitic infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 299-86-5
分子式: C₁₂H₁₉ClNO₃P
分子量:291.71

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Crufomate 構造式

CAS 番号: 299-86-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体内実験

Crufomate (50-100 mg/kg; dermal; 2 doses 14 days apart or 4 total doses 14 days apart) reduces female mouse mating response to 30-50% and conception rate to 10% with two dermal pre-mating treatments, while four dermal treatments with 100 mg/kg crufomate significantly reduce both female and male progeny weaning weight without affecting mature weight^[1].
Crufomate (19.1-21.2 mg/kg; topical; single application) results in mean milk residues that fall below the 0.05 mg/kg Codex limit within 24 hours post-treatment, with residue accumulation in fat-rich milk products leading to higher concentrations relative to whole milk in lactating dairy cows^[2].
Crufomate (50.8 mg/kg; topical; single dose) demonstrates no anthelmintic effect on abomasal helminths and erratic, questionable efficacy on intestinal helminths in calves with mixed gastrointestinal parasite infections^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

White virgin female mice (10-12 weeks old; reproductive toxicity model via dermal exposure before mating)^[1]
Dosage:

100 mg/kg (2 treatments; 4 treatments); 50 mg/kg (2 treatments; 4 treatments)
Administration:

dermal; 2 doses 14 days apart; 4 total doses 14 days apart
Result:

Reduced mating response to 30% (100 mg/kg, 2 treatments) and 50% (50 mg/kg, 2 treatments).
Slashed conception rate to 10% at 50 and 100 mg/kg (2 treatments).
Left only one pregnant mouse per 2-treatment group; the 100 mg/kg mouse died mid-pregnancy, and the 50 mg/kg mouse lost all pups within one week after birth.
Lessened female pup weaning weight to 12.0 g (100 mg/kg, 4 treatments).
Cut male pup weaning weight to 11.7 g (100 mg/kg, 4 treatments).
Had no effect on adult pup weight at all doses and treatment regimens.
Altered none of pup weaning/adult weight, mating response, conception rate or litter survival (50 mg/kg, 4 treatments).

化学情報

CAS 番号 299-86-5
分子量 291.71
分子式 C₁₂H₁₉ClNO₃P
SMILES

O=P(OC)(NC)OC1=CC=C(C(C)(C)C)C=C1Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Khan MA, et al. Reproduction in mice treated with crufomate: effects of dermal treatments on female mice and on their progeny. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1978;13(3):169-81. [Content Brief]

[2]. O'Keeffe M, et al. Crufomate residues in milk and milk products following treatment of dairy cows for warble-fly. Journal of the Science of Food and Agriculture, 1982, 33(4): 355-360.

[3]. Poole J B, et al. Anthelmintic efficacy of topically applied crufomate against gastrointestinal parasites in cattle. American Journal of Veterinary Research, 1972, 33(5): 1063.

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