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製品番号: HY-185107

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CTR/AMYR modulator-2

CTR/AMYR modulator-2 is a dual agonist of human amylin receptor 3 (AMY3R) and calcitonin receptor (CTR). CTR/AMYR modulator-2 activates AMY3R and CTR, stimulating Rel EC₅₀ of cAMP production in UMUC3 cells by 4 nM and 1 nM, respectively. CTR/AMYR modulator-2 may be used in research on type 2 diabetes and obesity.

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CAS 番号: 3108095-52-6
分子式: C₃₃H₃₅ClF₂N₈O₃
分子量:665.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CTR/AMYR modulator-2 構造式

CAS 番号: 3108095-52-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

AMY3R

4 nM (EC₅₀)

CTR

1 nM (EC₅₀)

体外実験

CTR/AMYR modulator‑2 (Example 107) acts as an agonist at the human amylin receptor (AMY3R) in UMUC3 cells, with a Rel EC₅₀ of 4 nM and an Emax of 99% as determined in a 20‑point concentration‑response assay following 30 min of incubation^[1].
CTR/AMYR modulator‑2 acts as an agonist at the human calcitonin receptor (CTR) in UMUC3 cells, with a Rel EC₅₀ of 1 nM and an Emax of 88% under the same 20‑point assay conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3108095-52-6
性状 Powder
分子量 665.13
分子式 C₃₃H₃₅ClF₂N₈O₃
SMILES

O=C(C1=C(CC(C)C)N=C2C(C=NN2C3CCN(C4CC(F)(C4)F)CC3)=C1C5=CC(OCC(N6CC7=NC=C(C=N7)Cl)=O)=C6C=C5)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Renato A. BAUER, et al. 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight. WO2025240893A1. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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