CVN14
CVN14 is a potent, selective and brain-penetrant CD38 inhibitor with human IC50 19 nM, mouse IC50 2.4 nM. CVN14 binds uncompetitively to form a complex with CD38 and ADPR, and inhibits CD38 enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2925663-26-7
- 分子式: C17H21F3N6O
- 分子量:382.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
CVN14 potently inhibits human CD38 with an IC50 of 19 nM and mouse CD38 with an IC50 of 2.4 nM[1].
CVN14 potently inhibits human CD38 activity in CHO-hCD38 cells with an IC50 of 19 nM[1].
CVN14 binds tightly to human CD38 with a Kd of 3.6 nM and a long dissociation half-life of 143 min[1].
CVN14 has favorable in vitro permeability across MDR1-MDCK cell monolayers with an efflux ratio of 0.90[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2925663-26-7
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分子量 382.38
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分子式 C17H21F3N6O
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SMILES
FC(F)(F)CN[C@H](CC1)CC[C@@H]1NC(C2=CC(C)=NC(N3C=NC=C3)=N2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CVN14 関連分類
HY-181543 関連分類
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