D-Cysteic acid
D-Cysteic acid is a competitive inhibitor of the aspartate:alanine antiporter (AspT) from Tetragenococcus halophilus. For L-aspartate self-exchange, D-Cysteic acid has a Ki of 0.14 mM and an IC50 of 0.19 mM; for L-alanine self-exchange, it has a Ki of 5.0 mM and an IC50 of 9.0 mM. D-Cysteic acid occupies a distinct substrate-binding site within the substrate transport pathway of AspT, preventing the binding of natural substrates to the transporter. D-Cysteic acid can be used in studies related to substrate recognition and transport mechanisms of transporters.
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- CAS 番号: 35554-98-4
- 分子式: C3H7NO5S
- 分子量:169.15
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
D-cysteic acid competitively inhibits L-aspartate and L-alanine self-exchange via reconstituted Tetragenococcus halophilus AspT, with greater potency against L-aspartate self-exchange (Ki = 0.14 mM; IC50 = 0.19 mM) than L-alanine self-exchange (Ki = 5.0 mM; IC50=9.0 mM)[1].
D-Cysteic acid is formed via oxidation of L-cysteine with performic acid at 50°C for 15 min[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 35554-98-4
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分子量 169.15
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分子式 C3H7NO5S
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SMILES
[C@@H](CS(=O)(=O)O)(C(O)=O)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)