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United States

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製品番号: HY-128028

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DAB-1

DAB-1 is an α-glucosidase and β-glucosidase inhibitor. DAB-1 also inhibits α-mannosidase, with an IC₅₀ of 49 μM against Jack bean α-mannosidase. DAB-1 exhibits IC₅₀ values of 7.8 μM and 0.69 μM against rice and Saccharomyces cerevisiae α-glucosidase, respectively, while its IC₅₀ values were 79 μM and 62 μM against almond and Aspergillus niger β-glucosidase, respectively. DAB-1 can be used in research related to metabolic diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 100937-52-8
分子式: C₅H₁₁NO₃
分子量:133.15

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DAB-1 構造式

CAS 番号: 100937-52-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

β-Glucosidase

α‑glucosidase

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	1 μM Compound: 1, D-AB1	Inhibition of glucagon-stimulated glycogenolysis in Wistar rat hepatocytes assessed as glucose release after 90 mins Inhibition of glucagon-stimulated glycogenolysis in Wistar rat hepatocytes assessed as glucose release after 90 mins	[PMID: 18258441]
Hepatocyte	IC₅₀	1 μM Compound: D-AB1	Inhibition of basal glycogenolysis in rat primary hepatocytes Inhibition of basal glycogenolysis in rat primary hepatocytes	[PMID: 18595718]
Hepatocyte	IC₅₀	1 μM Compound: M1, DAB	Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis	[PMID: 23378626]
Hepatocyte	IC₅₀	1.1 μM Compound: M1, DAB	Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis	[PMID: 23378626]
Hepatocyte	IC₅₀	9 μM Compound: D-AB1	Inhibition of glucagon-induced glucose production in rat primary hepatocytes Inhibition of glucagon-induced glucose production in rat primary hepatocytes	[PMID: 18595718]
MOLT-4	CC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells	[PMID: 7608901]
MOLT-4	EC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells	[PMID: 7608901]
MT4	CC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of growth of mock-infected MT-4 cells Concentration giving 50% inhibition of growth of mock-infected MT-4 cells	[PMID: 7608901]
MT4	EC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells	[PMID: 7608901]

体外実験

DAB-1 (1 mM; pre-incubation for 5 minutes; reaction for 10-15 minutes) shows weak inhibition against Aspergillus orizae β-galactosidase, Aspergillus niger α-rhamnosidase, green coffee bean α-galactosidase, and jack bean β-N-acetylglucosaminidase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Double or multiplex chromogenic IHC

化学情報

CAS 番号 100937-52-8
分子量 133.15
分子式 C₅H₁₁NO₃
SMILES

C(O)[C@@H]1[C@@H](O)[C@H](O)CN1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lamara KO, et al. A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold. Molecules (Basel, Switzerland). 2025 Jan 08;30(2):226.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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