DAT1
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.
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- CAS 番号: 107401-70-7
- 分子式: C17H15N3O2S
- 分子量:325.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
300 nM
Compound: 5e
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Antiproliferative activity against human CEM cells after 2 days by coulter counter method
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
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[PMID: 19663386] |
| FM3A | IC50 |
730 nM
Compound: 5e
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Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
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[PMID: 19663386] |
| HeLa | IC50 |
230 nM
Compound: 5e
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Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
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[PMID: 19663386] |
| L1210 | IC50 |
850 nM
Compound: 5e
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Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
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[PMID: 19663386] |
| MOLT-4 | IC50 |
230 nM
Compound: 5e
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Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
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[PMID: 19663386] |
DAT1 shows cytotoxicity with GI50 values ranging from 0.05 to 1 μM in different malignant cell lines (human tumour cells from cervix, colon and lung and mouse fibrosarcoma cells) with an average value of 0.35 μM. DAT1 blocks mitosis in the prometaphase and metaphase stages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 107401-70-7
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分子量 325.38
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分子式 C17H15N3O2S
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SMILES
O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. [Content Brief]
[2]. Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DAT1 関連分類
HY-113722 関連分類
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