Dazukibart
Based on 1 Customer Validation
Dazukibart (PF‑06823859) is a humanized IgG1 monoclonal antibody targeting IFN‑β that binds to and neutralizes IFN-β. Dazukibart can be used in research on autoimmune inflammatory diseases such as dermatomyositis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.9%
- CAS 番号: 2639474-65-8
- 分子量:145.36 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IFNB1
体外実験
Dazukibart neutralizes IFN-β and inhibits downstream type I interferon-dependent inflammatory signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Animal-Free IFN-beta Protein, Human (His, HY-P700090AF) can bind Dazukibart. The EC50 for this effect is 11.01 ng/mL.
化学情報
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CAS 番号 2639474-65-8
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性状 Liquid
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分子量 145.36 kDa
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Color Colorless to light yellow
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SMILES
[Dazukibart]
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別名
PF-06823859
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)