DC_M5_2
DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC50 of 9.63 μM and a KD of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction. DC_M5_2 can be used in leukemia-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 713099-37-7
- 分子式: C22H22BrNO5
- 分子量:460.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
DC_M5_2 inhibits the WDR5-MLL1 interaction with an IC50 of 9.63 µM by binding to WDR5 through hydrophobic contacts and hydrogen bonds[1].
DC_M5_2 binds directly to purified WDR5 protein in vitro with a Kd of 13.8 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 713099-37-7
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分子量 460.32
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分子式 C22H22BrNO5
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SMILES
O=C(COC1=CC=C(C=C1C2C3=C(N(C)C4=C2C(CCC4)=O)CCCC3=O)Br)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gurung R, et al. Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders. Cancers (Basel). 2023;15(15):3910. Published 2023 Aug 1. [Content Brief]
[2]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019;29(4):638-645. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DC_M5_2 関連分類
HY-183959 関連分類
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