Deferitrin
Based on 1 Customer Validation
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.25%
- CAS 番号: 239101-33-8
- 分子式: C11H11NO4S
- 分子量:253.27
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
19 μM
Compound: 8 ((S)-4'(HO)-DADFT)
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Inhibitory concentration against growth of murine L1210 cells at 48 hours
Inhibitory concentration against growth of murine L1210 cells at 48 hours
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[PMID: 15943485] |
| L1210 | IC50 |
20 μM
Compound: 8 ((S)-4'(HO)-DADFT)
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Inhibitory concentration against growth of murine L1210 cells at 96 hours
Inhibitory concentration against growth of murine L1210 cells at 96 hours
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[PMID: 15943485] |
体外実験
The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 μmol/kg is shown to be 1.1%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 239101-33-8
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性状 Solid
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分子量 253.27
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分子式 C11H11NO4S
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Color Off-white to light yellow
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SMILES
O=C([C@]1(C)N=C(C2=CC=C(O)C=C2O)SC1)O
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別名
GT-56-252
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (493.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51(13):3913-23. [Content Brief]
[2]. Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9484 mL | 19.7418 mL | 39.4836 mL | 98.7089 mL |
| 5 mM | 0.7897 mL | 3.9484 mL | 7.8967 mL | 19.7418 mL | |
| 10 mM | 0.3948 mL | 1.9742 mL | 3.9484 mL | 9.8709 mL | |
| 15 mM | 0.2632 mL | 1.3161 mL | 2.6322 mL | 6.5806 mL | |
| 20 mM | 0.1974 mL | 0.9871 mL | 1.9742 mL | 4.9354 mL | |
| 25 mM | 0.1579 mL | 0.7897 mL | 1.5793 mL | 3.9484 mL | |
| 30 mM | 0.1316 mL | 0.6581 mL | 1.3161 mL | 3.2903 mL | |
| 40 mM | 0.0987 mL | 0.4935 mL | 0.9871 mL | 2.4677 mL | |
| 50 mM | 0.0790 mL | 0.3948 mL | 0.7897 mL | 1.9742 mL | |
| 60 mM | 0.0658 mL | 0.3290 mL | 0.6581 mL | 1.6451 mL | |
| 80 mM | 0.0494 mL | 0.2468 mL | 0.4935 mL | 1.2339 mL | |
| 100 mM | 0.0395 mL | 0.1974 mL | 0.3948 mL | 0.9871 mL |
Deferitrin 関連分類
HY-108260 関連分類
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