Dehydrojuncusol
Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC50=1.35?μM).
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- CAS 番号: 117824-04-1
- 分子式: C18H16O2
- 分子量:264.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
15.6 μM
Compound: Dehydrojuncusol
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production
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[PMID: 29280630] |
Dehydrojuncusol (Huh-7 cells were infected with HCV in cell culture; 0-9.4 μM; 48 hours) inhibits HCV infection in a dose-dependent manner. Dehydrojuncusol inhibits HCV infection in Primary human hepatocytes (PHH)[1].
The EC50 of dehydrojuncusol is 1.35 μM when added continuously, 8.21 μM when added during inoculation, and 1.53 μM when added postinoculation, confirming the major effect of the molecule at the postinoculation step. The toxicity of the compound on Huh-7 cells is also tested in parallel at different time points (24 h, 48 h, and 72 h). The results shows that the CC50 of Dehydrojuncusol Is approximately 75.6 μM, which is much higher than the active dose, yielding a selective index of 56[1].
Dehydrojuncusol is able to inhibit RNA replication of two frequent daclatasvir-resistant mutants (L31M or Y93H in NS5A). Dehydrojuncusol inhibits HCV RNA replication[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 117824-04-1
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分子量 264.32
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分子式 C18H16O2
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SMILES
OC1=CC=C2C3=C(C=C)C(C)=C(O)C=C3C=CC2=C1C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dehydrojuncusol 関連分類
HY-N8188 関連分類
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