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製品番号: HY-183434

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Desoxymansil

Desoxymansil is an anti-schistosomal agent. In mice, rabbits, dogs and monkeys, Desoxymansil undergoes oxidative metabolism via its isopropylaminomethyl side chain to produce a carboxylic acid metabolite, while this metabolic pathway is absent in rats. In rats, Desoxymansil undergoes α-carbon oxidation of the side chain to form an unstable aminomethanol that decomposes; the intermediate product is reduced to an alcohol metabolite, which is excreted in bile in the form of glucuronide. Desoxymansil can be used for the study of schistosomiasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 21738-41-0
分子式: C₁₄H₂₁N₃O₂
分子量:263.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Desoxymansil 構造式

CAS 番号: 21738-41-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Desoxymansil (2.0 μmol; 30 min) is extensively hydroxylated to oxamniquine by liver microsomes from rat, mouse, and rabbit, with no detectable N-dealkylation of the isopropyl group^[1].
Desoxymansil is converted to carboxylic acid metabolite V by whole liver homogenates from rabbit and mouse, while rat whole liver homogenates do not produce this metabolite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Desoxymansil (15-30 mg/kg; i.p.; single dose) administered intraperitoneally to healthy male Wistar rats results in biliary excretion of metabolites III and VI, with no detection of metabolite V, and total biliary radioactivity excretion is higher at the 15 mg/kg dose (28.5%) than at the 30 mg/kg dose (14.7%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male, 250-300 g)^[1]
Dosage:

15 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Excreted 28.5% of the total administered dose in bile as radioactivity, with 9.1% of the dose present as metabolite III and 4.0% as metabolite VI.
Excreted 14.7% of the total administered dose in bile as radioactivity, with 3.5% of the dose present as metabolite III and 2.8% as metabolite VI.
Detected no metabolite V in bile samples.

化学情報

CAS 番号 21738-41-0
分子量 263.34
分子式 C₁₄H₂₁N₃O₂
SMILES

CC(C)NCC1NC(C=C2[N+]([O-])=O)=C(C=C2C)CC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Woolhouse NM, Kaye B, Parke DV. Species differences in N-dealkylation of oxamniquine. Xenobiotica. 1979;9(5):323-332.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
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化学情報
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Desoxymansil

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Desoxymansil 関連分類

HY-183434 関連分類