Diorcinol
Based on 1 Customer Validation
Diorcinol is a potent SHP1 inhibitor with an IC50 value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.30%
- CAS 番号: 20282-75-1
- 分子式: C14H14O3
- 分子量:230.26
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
31.6 μM
Compound: 52
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
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[PMID: 33691166] |
| HL-60 | IC50 |
>10 μM
Compound: 14
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Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
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[PMID: 23527875] |
| K562 | IC50 |
>10 μM
Compound: 14
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Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
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[PMID: 23527875] |
| NCI-H157 | IC50 |
20.2 μM
Compound: 52
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Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
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[PMID: 33691166] |
| Neutrophil | IC50 |
>10 μg/mL
Compound: 11
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
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[PMID: 23647825] |
| Neutrophil | IC50 |
12.21 μM
Compound: 11
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
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[PMID: 23647825] |
化学情報
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CAS 番号 20282-75-1
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性状 Solid
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分子量 230.26
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分子式 C14H14O3
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Color White to off-white
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SMILES
OC1=CC(C)=CC(OC2=CC(O)=CC(C)=C2)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (542.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3429 mL | 21.7146 mL | 43.4292 mL | 108.5729 mL |
| 5 mM | 0.8686 mL | 4.3429 mL | 8.6858 mL | 21.7146 mL | |
| 10 mM | 0.4343 mL | 2.1715 mL | 4.3429 mL | 10.8573 mL | |
| 15 mM | 0.2895 mL | 1.4476 mL | 2.8953 mL | 7.2382 mL | |
| 20 mM | 0.2171 mL | 1.0857 mL | 2.1715 mL | 5.4286 mL | |
| 25 mM | 0.1737 mL | 0.8686 mL | 1.7372 mL | 4.3429 mL | |
| 30 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6191 mL | |
| 40 mM | 0.1086 mL | 0.5429 mL | 1.0857 mL | 2.7143 mL | |
| 50 mM | 0.0869 mL | 0.4343 mL | 0.8686 mL | 2.1715 mL | |
| 60 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8095 mL | |
| 80 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.3572 mL | |
| 100 mM | 0.0434 mL | 0.2171 mL | 0.4343 mL | 1.0857 mL |
Diorcinol 関連分類
HY-N12614 関連分類
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