DKI5
Based on 1 Customer Validation
DKI5 is a LOX-1 inhibitor with a soybean IC50 of 22.5 μM. DKI5 binds to the active site and affects the catalytic iron center. DKI5 inhibits lipid peroxidation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.12%
- CAS 番号: 1101130-96-4
- 分子式: C8H10N4S
- 分子量:194.26
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
LOX-1 22.5 μM (IC50) |
体外実験
DKI5 (0.01-100 μM) inhibits soybean lipoxygenase (LOX-1) with an IC50 of 22.5 μM in the sodium linoleate conversion assay[1].
DKI5 (100 μM) inhibits AAPH-induced lipid peroxidation in the sodium linoleate assay by 94%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1101130-96-4
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性状 Solid
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分子量 194.26
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分子式 C8H10N4S
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Color White to off-white
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SMILES
NNC(N/N=C/C1=CC=CC=C1)=S
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (257.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1477 mL | 25.7387 mL | 51.4774 mL | 128.6935 mL |
| 5 mM | 1.0295 mL | 5.1477 mL | 10.2955 mL | 25.7387 mL | |
| 10 mM | 0.5148 mL | 2.5739 mL | 5.1477 mL | 12.8694 mL | |
| 15 mM | 0.3432 mL | 1.7159 mL | 3.4318 mL | 8.5796 mL | |
| 20 mM | 0.2574 mL | 1.2869 mL | 2.5739 mL | 6.4347 mL | |
| 25 mM | 0.2059 mL | 1.0295 mL | 2.0591 mL | 5.1477 mL | |
| 30 mM | 0.1716 mL | 0.8580 mL | 1.7159 mL | 4.2898 mL | |
| 40 mM | 0.1287 mL | 0.6435 mL | 1.2869 mL | 3.2173 mL | |
| 50 mM | 0.1030 mL | 0.5148 mL | 1.0295 mL | 2.5739 mL | |
| 60 mM | 0.0858 mL | 0.4290 mL | 0.8580 mL | 2.1449 mL | |
| 80 mM | 0.0643 mL | 0.3217 mL | 0.6435 mL | 1.6087 mL | |
| 100 mM | 0.0515 mL | 0.2574 mL | 0.5148 mL | 1.2869 mL |
DKI5 関連分類
HY-149922 関連分類
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