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製品番号: HY-182395

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DM175

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454.

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CAS 番号: 832119-34-3
分子式: C₂₅H₂₄N₂O₄
分子量:416.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DM175 構造式

CAS 番号: 832119-34-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454^[1].

体外実験

DM175 is a partial agonist of FXR LBD, which induces the outward movement of Trp454, a conformational change distinct from that induced by full FXR agonists^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 832119-34-3
分子量 416.47
分子式 C₂₅H₂₄N₂O₄
SMILES

O=C(C1=CC=C(NC(C2=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=CC=C2)=O)C=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Miyata S, et al. Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists. Sci Rep. 2021;11(1):9196. Published 2021 Apr 28. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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